KCTBASE

뇌척수액과 말초혈액 내 알츠하이머병의 생화학적 생체표지자
Biochemical Biomarkers for Alzheimer’s Disease in Cerebrospinal Fluid and Peripheral Blood

노인정신의학 2012년 16권 1호 p.17 ~ p.23

이영민(Lee Young-Min) - 부산대학교 의과대학 정신건강의학교실
최원정(Choi Won-Jung) - 연세대학교 의과대학 정신건강의학교실
박민선(Park Min-Sun) - 연세대학교 의과대학 정신건강의학교실
김어수(Kim Eo-Su) - 연세대학교 의과대학 정신건강의학교실

Abstract

The diagnosis of Alzheimer’s disease (AD) is still obscure even to specialists. To improve the diagnostic accuracy, to find at-risk people as early as possible, to predict the efficacy or adverse reactions of pharmacotherapy on an individual basis, to attain more reliable results of clinical trials by recruiting better defined participants, to prove the disease-modifying ability of new candidate drugs, to establish prognosis-based therapeutic plans, and to do more, is now increasing the need for biomarkers for AD. Among AD-related biochemical markers, cerebrospinal beta-amyloid and tau have been paid the most attention since they are materials directly interfacing the brain interstitium and can be obtained through the lumbar puncture. Level of beta-amyloid is reduced whereas tau is increased in cerebrospinal fluid of AD patients relative to cognitively normal elderly people. Remarkably, such information has been found to help predict AD conversion of mild cognitive impairment. Despite inconsistent findings from previous studies, plasma beta-amyloid is thought to be increased before the disease onset, but show decreasing change as the disease progress. Regarding other peripheral biochemical markers, omics tools are being widely used not only to find useful biomarkers but also to generate novel hypotheses for AD pathogenesis and to lead new personalized future medicine.

키워드

알츠하이머병, 생체표지자, 베타 아밀로이드, 타우, 오믹스, 혈장

Alzheimer’s disease, Biomarker, Beta-amyloid, Tau, Omics, Plasma

KMID : 0869220120160010017

원문 및 링크아웃 정보

등재저널 정보

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

Level of beta-amyloid is reduced whereas tau is increased in cerebrospinal fluid of AD patients relative to cognitively normal elderly people. Remarkably, such information has been found to help predict AD conversion of mild cognitive impairment.

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

KCD코드

ICD 03

건강보험코드

뇌척수액과 말초혈액 내 알츠하이머병의 생화학적 생체표지자 Biochemical Biomarkers for Alzheimer’s Disease in Cerebrospinal Fluid and Peripheral Blood

Abstract

키워드

뇌척수액과 말초혈액 내 알츠하이머병의 생화학적 생체표지자
Biochemical Biomarkers for Alzheimer’s Disease in Cerebrospinal Fluid and Peripheral Blood